Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up.
نویسندگان
چکیده
The association between bronchiolitis and recurrent wheezing remains controversial. In this prospective study, we assessed risk factors for recurrent wheezing during a 12-month follow-up in 313 infants aged <12 months hospitalised for their first episode of bronchiolitis. Demographic, clinical and laboratory data were obtained with a questionnaire and from medical files. A total of 14 respiratory viruses were concurrently assayed in nasal washings. Parents were interviewed 12 months after hospitalisation to check whether their infants experienced recurrent wheezing. The rate of recurrent wheezing was higher in infants with bronchiolitis than in controls (52.7 versus 10.3%; p<0.001). Multivariate analysis identified rhinovirus (RV) infection (OR 3.3, 95% CI 1.0-11.1) followed by a positive family history for asthma (OR 2.5, 95% CI 1.2-4.9) as major independent risk factors for recurrent wheezing. In conclusion, the virus most likely to be associated with recurrent wheezing at 12 months after initial bronchiolitis is RV, a viral agent that could predict infants prone to the development of recurrent wheezing.
منابع مشابه
Rhinovirus infection in children hospitalized with acute bronchiolitis and its impact on subsequent wheezing or asthma: a comparison of etiologies.
BACKGROUD Children who suffer a viral lower respiratory infection early in life are prone to subsequent wheezing and asthma: RSV and rhinovirus are thought to be the primary causative pathogens. Epidemiologic and long-term data on these pathogens in Thailand are limited. OBJECTIVES To detect the causative pathogens in children hospitalized with a first episode of acute wheezing and to compare...
متن کاملDexamethasone for bronchiolitis.
To the Editor: The prospective trial of dexamethasone for bronchiolitis in infants, conducted by the Bronchiolitis Study Group of the Pediatric Emergency Care Applied Research Network (PECARN) and reported by Corneli et al. (July 26 issue),1 appears to demonstrate a lack of efficacy of oral dexamethasone in infants with a first episode of wheezing diagnosed as bronchiolitis. Although the author...
متن کاملSix-month to 3-year follow-up of children with acute respiratory infections caused by respiratory syncytial virus
Background and Objective: This study was performed to investigate long-term complications of Respiratory Syncytial Viral infections in patients admitted to Ali Asghar Hospital with acute respiratory infections who presented to follow-up outpatient clinics 6 months to 3 years after discharge, between years 2009 and 2011. Methods: In this retrospective observational study that was performed in a...
متن کاملCellular and humoral immunity of virus-induced asthma
Asthma inception is associated with respiratory viral infection, especially infection with respiratory syncytial virus (RSV) and/or human rhinovirus (HRV), in the vast majority of cases. However, the reason why RSV and HRV induce the majority of bronchiolitis cases during early childhood and why only a small percentage of children with RSV- and HRV-induced bronchiolitis later develop asthma rem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The European respiratory journal
دوره 39 2 شماره
صفحات -
تاریخ انتشار 2012